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Apigenin, in turn, promotes TRAIL-induced apoptosis in human RA-FLS and inhibits TRAIL-dependent proliferation of RA-FLS by increasing the expression and activity of caspase-3, decreasing the ratio of Bcl-2/Bax, restoring the expression of cell cycle inhibitors p21 and p27, and activating the PI3K/AKT signaling pathway

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